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Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because lower cAMP levels may contribute to the decreased apoptosis that occurs in chronic lymphocytic leukemia (CLL), we assessed the expression levels of PDE isoforms in peripher...

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Библиографические подробности
Главные авторы: Zhang, Lingzhi, Murray, Fiona, Zahno, Anja, Kanter, Joan R., Chou, Daisy, Suda, Ryan, Fenlon, Michael, Rassenti, Laura, Cottam, Howard, Kipps, Thomas J., Insel, Paul A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614795/
https://ncbi.nlm.nih.gov/pubmed/19033455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806152105
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