Mitochondrial RNA and DNA alterations in subcutaneous fat tissue of HIV+ subjects with lipoatrophy are linked to antiretroviral therapy and not to HIV infection

OBJECTIVE: Assess the effect of ART versus HIV on fat mitochondria. METHODS: Subcutaneous-fat was collected from 45 HIV-infected subjects on ART with lipoatrophy, 11 HIV-infected ART-naïve, and 9 healthy-controls. Three mt-transcripts NADH-dehydrogenase subunit 1(ND1), cytochrome-b (CYTB), and NADH-...

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Main Authors: McComsey, Grace A, Libutti, Daniel E, O’Riordan, MaryAnn, Shelton, Jessica M, Storer, Norma, Ganz, Jason, Jasper, John, Harrill, Danielle, Gerschenson, Mariana
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614396/
https://ncbi.nlm.nih.gov/pubmed/18771055
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