Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum: an entero-bone endocrine axis

Loss- and gain-of-function mutations in the broadly expressed gene Lrp5 affect bone formation causing osteoporosis and high bone mass, respectively. Although Lrp5 is viewed as a Wnt coreceptor osteoblast-specific disruption of β-Catenin does not affect bone formation. Instead, we show here that Lrp5...

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Hauptverfasser: Yadav, Vijay K., Ryu, Je-Hwang, Suda, Nina, Tanaka, Kenji, Gingrich, Jay A., Schütz, Günther, Glorieux, Francis H., Chiang, Cherie Y., Zajac, Jeffrey D, Insogna, Karl L., Mann, J. John, Hen, Rene, Ducy, Patricia, Karsenty, Gerard
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614332/
https://ncbi.nlm.nih.gov/pubmed/19041748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.09.059
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