HER receptor signaling confers resistance to the insulin-like growth factor 1 receptor inhibitor, BMS-536924

We have previously reported the activity of the IGF-1R/InsR inhibitor, BMS-554417, in breast and ovarian cancer cell lines. Further studies indicated treatment of OV202 ovarian cancer cells with BMS-554417 increased phosphorylation of HER2. In addition, treatment with the panHER inhibitor, BMS-59962...

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Detalhes bibliográficos
Main Authors: Haluska, Paul, Carboni, Joan M., Eyck, Cynthia Ten, Attar, Ricardo M., Hou, Xiaonan, Yu, Chunrong, Sagar, Malvika, Wong, Tai W., Gottardis, Marco M., Erlichman, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614316/
https://ncbi.nlm.nih.gov/pubmed/18765823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0493
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