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A Simple Derivation of the Distribution of Pairwise Local Protein Sequence Alignment Scores
Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic data. In the asymptotic limit of long sequences, the Karlin-Altschul model computes a P-value assuming that the number of high scoring...
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Libertas Academica
2008
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2614193/ https://ncbi.nlm.nih.gov/pubmed/19204806 |
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