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Alkyltransferase-mediated Toxicity of 1,3-Butadiene Diepoxide
Human O(6)-alkylguanine-DNA alkyltransferase (hAGT) expression increases mutations and cytotoxicity following exposure to 1,3-butadiene diepoxide (BDO) and hAGT-DNA cross-links are formed in the presence of BDO. We have used hAGT mutants to investigate the mechanism of cross-link formation and genot...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2614079/ https://ncbi.nlm.nih.gov/pubmed/18712882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800178t |
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