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Alkyltransferase-mediated Toxicity of 1,3-Butadiene Diepoxide

Human O(6)-alkylguanine-DNA alkyltransferase (hAGT) expression increases mutations and cytotoxicity following exposure to 1,3-butadiene diepoxide (BDO) and hAGT-DNA cross-links are formed in the presence of BDO. We have used hAGT mutants to investigate the mechanism of cross-link formation and genot...

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Detalhes bibliográficos
Main Authors: Kalapila, Aley G., Loktionova, Natalia A., Pegg, Anthony E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614079/
https://ncbi.nlm.nih.gov/pubmed/18712882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800178t
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