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A multicenter phase II trial of intrathecal topotecan in patients with meningeal malignancies

To determine the therapeutic efficacy (13-week and 26-week CNS progression-free survival [PFS], response rate, and overall survival) and safety of intraventricular (IVent) topotecan in patients with neoplastic meningitis (NM), we conducted a phase II, open-label, nonrandomized, single-arm trial of I...

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Detalhes bibliográficos
Main Authors: Groves, Morris D., Glantz, Michael J., Chamberlain, Marc C., Baumgartner, Karen E., Conrad, Charles A., Hsu, Sigmund, Wefel, Jeffrey S., Gilbert, Mark R., Ictech, Sandra, Hunter, Kathy U., Forman, Arthur D., Puduvalli, Vinay K., Colman, Howard, Hess, Kenneth R., Yung, W.K. Alfred
Formato: Artigo
Idioma:Inglês
Publicado em: Duke University Press 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613823/
https://ncbi.nlm.nih.gov/pubmed/18316473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2007-059
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