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DNA-PK suppresses a p53-independent apoptotic response to DNA damage
p53 is required for DNA damage-induced apoptosis, which is central to its function as a tumour suppressor. Here, we show that the apoptotic defect of p53-deficient cells is nearly completely rescued by inactivation of any of the three subunits of the DNA repair holoenzyme DNA-dependent protein kinas...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2613202/ https://ncbi.nlm.nih.gov/pubmed/19057578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.214 |
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