Effect of thiol-activated toxins (streptolysin O, alveolysin, and theta toxin) on the generation of leukotrienes and leukotriene-inducing and -metabolizing enzymes from human polymorphonuclear granulocytes.

The generation of leukotrienes (LTC4, LTD4, LTE4, and LTB4; 12-epi-LTB4 isomer) from human granulocytes by thiol-activated toxins (streptolysin O, alveolysin from Bacillus alvei, and theta toxin from Clostridium perfringens) is described. The release occurs under noncytolytic conditions. Although LT...

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Pubblicato in:	Infect Immun
Autori principali:	Bremm, K D, König, W, Pfeiffer, P, Rauschen, I, Theobald, K, Thelestam, M, Alouf, J E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1985
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC261157/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2866160/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.50.3.844-851.1985
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