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Discovery of Novel Nitrobenzothiazole Inhibitors for M. tuberculosis ATP Phosphoribosyl Transferase (HisG) through Virtual Screening

HisG represents a potential drug target for tuberculosis. HisG is an ATP-phosphoribosyl transferase (ATP-PRTase) that catalyzes the first step in the biosynthetic pathway for histidine. Only a few inhibitors with limited potency for HisG are currently known. In order to discover more potent and dive...

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Main Authors: Cho, Yoonsang, Ioerger, Thomas R., Sacchettini, James C.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610488/
https://ncbi.nlm.nih.gov/pubmed/18778048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800328v
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