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Discovery of Novel Nitrobenzothiazole Inhibitors for M. tuberculosis ATP Phosphoribosyl Transferase (HisG) through Virtual Screening
HisG represents a potential drug target for tuberculosis. HisG is an ATP-phosphoribosyl transferase (ATP-PRTase) that catalyzes the first step in the biosynthetic pathway for histidine. Only a few inhibitors with limited potency for HisG are currently known. In order to discover more potent and dive...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2610488/ https://ncbi.nlm.nih.gov/pubmed/18778048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800328v |
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