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Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-β/BMP signaling during tooth and palate development

Smad4 is a central intracellular effector of TGF-β signaling. Smad-independent TGF-β pathways, such as those mediated by p38 MAPK, have been identified in cell culture systems, but their in vivo functional mechanisms remain unclear. In this study, we investigated the role of TGF-β signaling in tooth...

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Autori principali: Xu, Xun, Han, Jun, Ito, Yoshihiro, Bringas, Pablo, Deng, Chuxia, Chai, Yang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610417/
https://ncbi.nlm.nih.gov/pubmed/18694570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2008.06.004
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