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A non-proteolytic function of separase links anaphase onset to mitotic exit
Separase is a protease that triggers chromosome segregation at anaphase onset by cleaving cohesin, the chromosomal protein complex responsible for sister chromatid cohesion1,2. After anaphase, cells exit from mitosis, i. e. they complete downregulation of cyclin-dependent kinase activity, undergo cy...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2610357/ https://ncbi.nlm.nih.gov/pubmed/12598903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb940 |
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