Mast cells contribute to autoimmune inflammatory arthritis via their tryptase•heparin complexes

Although mast cells (MCs) often are abundant in the synovial tissues of patients with rheumatoid arthritis (RA), MC’s contribution to joint inflammation and cartilage loss remains poorly understood. MC-restricted tryptase•heparin complexes have pro-inflammatory activity, and significant amounts of h...

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Autori principali: Shin, Kichul, Nigrovic, Peter A., Crish, James, Boilard, Eric, McNeil, H. Patrick, Larabee, Katherine S., Adachi, Roberto, Gurish, Michael F., Gobezie, Reuben, Stevens, Richard L., Lee, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610352/
https://ncbi.nlm.nih.gov/pubmed/19109198
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