Light-induced translocation of cyclic-GMP phosphodiesterase on rod disc membranes in rat retina

PURPOSE: Cyclic GMP phosphodiesterase (PDE) is the light-regulated effector enzyme of vertebrate rods. Upon photo-activation of rhodopsin followed by activation of transducin/GTP, PDE rapidly hydrolyzes 3′, 5′-cyclic GMP (cGMP) to 5′-GMP, which results in closure of cGMP-dependent ion channels and g...

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Main Authors: Chen, Jing, Yoshida, Tatsuro, Bitensky, Mark W.
Format: Artigo
Sprog:Inglês
Udgivet: Molecular Vision 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610287/
https://ncbi.nlm.nih.gov/pubmed/19112528
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