Slow delayed rectifier K(+) current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles

BACKGROUND AND PURPOSE: The slow delayed rectifier K(+) current (I(Ks)) contributes to ventricular repolarization when the action potential (AP) is prolonged. I(Ks) block during drug-induced AP prolongation may promote Torsades de Pointes (TdP), but whether this is due to additional AP prolongation...

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Detalhes bibliográficos
Main Authors: So, P P-S, Backx, P H, Dorian, P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2607203/
https://ncbi.nlm.nih.gov/pubmed/18836478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.354
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