Desensitization of the soluble guanylyl cyclase/cGMP pathway by lipopolysaccharide in rat isolated pulmonary artery but not aorta

BACKGROUND AND PURPOSE: To investigate the function of soluble guanylyl cyclase (sGC)/3′,5′-cyclic guanosine monophosphate (cGMP) pathway in lipopolysaccharide (LPS)-induced changes in vascular reactivity of rat isolated pulmonary artery and aorta. EXPERIMENTAL APPROACH: Nitric oxide (NO) production...

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Autori principali: El-Awady, M S H, Smirnov, S V, Watson, M L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2008
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2607199/
https://ncbi.nlm.nih.gov/pubmed/18806822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.358
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