Loading...

Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor

Degradation of the extracellular matrix (ECM) protein laminin contributes to excitotoxic cell death in the hippocampus, but the mechanism of this effect is unknown. To study this process, we disrupted laminin γ1 (lamγ1) expression in the hippocampus. Lamγ1 knockout (KO) and control mice had similar...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Chen, Zu-Lin, Yu, Huaxu, Yu, Wei-Ming, Pawlak, Robert, Strickland, Sidney
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606967/
https://ncbi.nlm.nih.gov/pubmed/19114596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200803107
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!