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Positive feedback of G1 cyclins ensures coherent cell cycle entry

In budding yeast, the Start checkpoint integrates multiple internal and external signals into an all-or-none decision to enter the cell cycle. Here, we show that Start behaves like a switch due to systems-level feedback in the regulatory network. In contrast to current models proposing a linear casc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Skotheim, Jan M., Di Talia, Stefano, Siggia, Eric D., Cross, Frederick R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606905/
https://ncbi.nlm.nih.gov/pubmed/18633409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07118
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