Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver

OBJECTIVE—To determine whether 1) hepatic ceramide and diacylglycerol concentrations, 2) SCD1 activity, and 3) hepatic lipogenic index are increased in the human nonalcoholic fatty liver. RESEARCH DESIGN AND METHODS—We studied 16 subjects with (n = 8) and without (n = 8) histologically determined no...

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Главные авторы: Kotronen, Anna, Seppänen-Laakso, Tuulikki, Westerbacka, Jukka, Kiviluoto, Tuula, Arola, Johanna, Ruskeepää, Anna-Liisa, Orešič, Matej, Yki-Järvinen, Hannele
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2009
Предметы:
Pathophysiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606873/
https://ncbi.nlm.nih.gov/pubmed/18952834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1074
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