Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver

OBJECTIVE—To determine whether 1) hepatic ceramide and diacylglycerol concentrations, 2) SCD1 activity, and 3) hepatic lipogenic index are increased in the human nonalcoholic fatty liver. RESEARCH DESIGN AND METHODS—We studied 16 subjects with (n = 8) and without (n = 8) histologically determined no...

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Hlavní autoři: Kotronen, Anna, Seppänen-Laakso, Tuulikki, Westerbacka, Jukka, Kiviluoto, Tuula, Arola, Johanna, Ruskeepää, Anna-Liisa, Orešič, Matej, Yki-Järvinen, Hannele
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2009
Témata:
Pathophysiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606873/
https://ncbi.nlm.nih.gov/pubmed/18952834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1074
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