Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice

OBJECTIVE—NOD mice model human type 1 diabetes and are used to investigate tolerance induction protocols for islet transplantation in a setting of autoimmunity. However, costimulation blockade–based tolerance protocols have failed in prolonging islet allograft survival in NOD mice. RESEARCH DESIGN A...

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Bibliographic Details
Main Authors: Mangada, Julie, Pearson, Todd, Brehm, Michael A., Wicker, Linda S., Peterson, Laurence B., Shultz, Leonard D., Serreze, David V., Rossini, Aldo A., Greiner, Dale L.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2009
Subjects:
Immunology and Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606867/
https://ncbi.nlm.nih.gov/pubmed/18984741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0275
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