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Skeletal Muscle–Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues
OBJECTIVE—Skeletal muscle–specific LPL knockout mouse (SMLPL(−/−)) were created to study the systemic impact of reduced lipoprotein lipid delivery in skeletal muscle on insulin sensitivity, body weight, and composition. RESEARCH DESIGN AND METHODS—Tissue-specific insulin sensitivity was assessed usi...
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| Auteurs principaux: | , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Diabetes Association
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2606858/ https://ncbi.nlm.nih.gov/pubmed/18952837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1839 |
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