Skeletal Muscle–Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues

OBJECTIVE—Skeletal muscle–specific LPL knockout mouse (SMLPL(−/−)) were created to study the systemic impact of reduced lipoprotein lipid delivery in skeletal muscle on insulin sensitivity, body weight, and composition. RESEARCH DESIGN AND METHODS—Tissue-specific insulin sensitivity was assessed usi...

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Auteurs principaux: Wang, Hong, Knaub, Leslie A., Jensen, Dalan R., Jung, Dae Young, Hong, Eun-Gyoung, Ko, Hwi-Jin, Coates, Alison M., Goldberg, Ira J., de la Houssaye, Becky A., Janssen, Rachel C., McCurdy, Carrie E., Rahman, Shaikh M., Choi, Cheol Soo, Shulman, Gerald I., Kim, Jason K., Friedman, Jacob E., Eckel, Robert H.
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2009
Sujets:
Obesity Studies
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606858/
https://ncbi.nlm.nih.gov/pubmed/18952837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1839
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