The Spinocerebellar Ataxia 12 Gene Product and Protein Phosphatase 2A Regulatory Subunit Bβ2 Antagonizes Neuronal Survival by Promoting Mitochondrial Fission

The neurodegenerative disorder spinocerebellar ataxia 12 (SCA12) is caused by CAG repeat expansion in the non-coding region of the PPP2R2B gene. PPP2R2B encodes Bβ1 and Bβ2, alternatively spliced and neuron-specific regulatory subunits of the protein phosphatase 2A (PP2A) holoenzyme. We show here th...

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Autors principals: Dagda, Ruben K., Merrill, Ronald A., Cribbs, J. Thomas, Chen, Yucui, Hell, Johannes W., Usachev, Yuriy M., Strack, Stefan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Molecular Basis of Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605997/
https://ncbi.nlm.nih.gov/pubmed/18940801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800989200
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