The Spinocerebellar Ataxia 12 Gene Product and Protein Phosphatase 2A Regulatory Subunit Bβ2 Antagonizes Neuronal Survival by Promoting Mitochondrial Fission

The neurodegenerative disorder spinocerebellar ataxia 12 (SCA12) is caused by CAG repeat expansion in the non-coding region of the PPP2R2B gene. PPP2R2B encodes Bβ1 and Bβ2, alternatively spliced and neuron-specific regulatory subunits of the protein phosphatase 2A (PP2A) holoenzyme. We show here th...

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Detalhes bibliográficos
Main Authors: Dagda, Ruben K., Merrill, Ronald A., Cribbs, J. Thomas, Chen, Yucui, Hell, Johannes W., Usachev, Yuriy M., Strack, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605997/
https://ncbi.nlm.nih.gov/pubmed/18940801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800989200
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