Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective α(1b)-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers

Many G-protein-coupled receptors, including the α(1b)-adrenoceptor, form homo-dimers or oligomers. Mutation of hydrophobic residues in transmembrane domains I and IV alters the organization of the α(1b)-adrenoceptor oligomer, with transmembrane domain IV playing a critical role. These mutations also...

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Autori principali: Canals, Meritxell, Lopez-Gimenez, Juan F., Milligan, Graeme
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605960/
https://ncbi.nlm.nih.gov/pubmed/18764782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20081227
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