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Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic β-cells

Using various biochemical, pharmacological and molecular biological approaches, we have recently reported regulatory roles for Rac1, a small G-protein, in glucose-stimulated insulin secretion [GSIS]. However, little is understood with respect to localization of, and regulation by, specific regulator...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Veluthakal, Rajakrishnan, Madathilparambil, Suresh Vasu, McDonald, Phillip, Olson, Lawrence Karl, Kowluru, Anjaneyulu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605786/
https://ncbi.nlm.nih.gov/pubmed/18930714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.09.021
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