Insights into the evolutionary origins of clostridial neurotoxins from analysis of the Clostridium botulinum strain A neurotoxin gene cluster

BACKGROUND: Clostridial neurotoxins (CNTs) are the most deadly toxins known and causal agents of botulism and tetanus neuroparalytic diseases. Despite considerable progress in understanding CNT structure and function, the evolutionary origins of CNTs remain a mystery as they are unique to Clostridiu...

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Bibliographic Details
Main Authors: Doxey, Andrew C, Lynch, Michael DJ, Müller, Kirsten M, Meiering, Elizabeth M, McConkey, Brendan J
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605760/
https://ncbi.nlm.nih.gov/pubmed/19014598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-8-316
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