dsRNA binding properties of RDE-4 and TRBP reflect their distinct roles in RNAi

dsRNA binding proteins (dsRBPs) facilitate Dicer functions in RNAi. C. elegans RDE-4 facilitates cleavage of long dsRNA to siRNA, while human TRBP functions downstream to pass siRNA to RISC. We show that these distinct in vivo roles are reflected in in vitro binding properties. RDE-4 preferentially...

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Bibliographic Details
Main Authors: Parker, Greg S., Maity, Tuhin Subhra, Bass, Brenda L.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605707/
https://ncbi.nlm.nih.gov/pubmed/18948111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.10.002
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