Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating progress toward β cell failure, and factors determining time of presentation of clinical diabetes are poorly understood. We investigated changes in the serum metabolome prospectively in children who la...

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Main Authors: Orešič, Matej, Simell, Satu, Sysi-Aho, Marko, Näntö-Salonen, Kirsti, Seppänen-Laakso, Tuulikki, Parikka, Vilhelmiina, Katajamaa, Mikko, Hekkala, Anne, Mattila, Ismo, Keskinen, Päivi, Yetukuri, Laxman, Reinikainen, Arja, Lähde, Jyrki, Suortti, Tapani, Hakalax, Jari, Simell, Tuula, Hyöty, Heikki, Veijola, Riitta, Ilonen, Jorma, Lahesmaa, Riitta, Knip, Mikael, Simell, Olli
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605239/
https://ncbi.nlm.nih.gov/pubmed/19075291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081800
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