Impact of Intranasal Insulin on Insulin Antibody Affinity and Isotypes in Young Children With HLA-Conferred Susceptibility to Type 1 Diabetes

OBJECTIVE: Despite promising results from studies on mouse models, intranasal insulin failed to prevent or delay the development of type 1 diabetes in autoantibody-positive children with HLA-conferred disease susceptibility. To analyze whether the insulin dose was inadequate to elicit an immunomodul...

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Detalhes bibliográficos
Main Authors: Ryhänen, Samppa J., Härkönen, Taina, Siljander, Heli, Näntö-Salonen, Kirsti, Simell, Tuula, Hyöty, Heikki, Ilonen, Jorma, Veijola, Riitta, Simell, Olli, Knip, Mikael
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114329/
https://ncbi.nlm.nih.gov/pubmed/21515841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc10-1449
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