TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus

Increased type I interferon (IFN-I) production and IFN-stimulated gene (ISG) expression are linked to the pathogenesis of systemic lupus erythematosus (SLE). Although the mechanisms responsible for dysregulated IFN-I production in SLE remain unclear, autoantibody-mediated uptake of endogenous nuclei...

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Detalhes bibliográficos
Main Authors: Lee, Pui Y., Kumagai, Yutaro, Li, Yi, Takeuchi, Osamu, Yoshida, Hideo, Weinstein, Jason, Kellner, Erinn S., Nacionales, Dina, Barker, Tolga, Kelly-Scumpia, Kindra, van Rooijen, Nico, Kumar, Himanshu, Kawai, Taro, Satoh, Minoru, Akira, Shizuo, Reeves, Westley H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605237/
https://ncbi.nlm.nih.gov/pubmed/19047436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080462
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