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An essential role for the MAL protein in targeting Lck to the plasma membrane of human T lymphocytes

The MAL protein is an essential component of the specialized machinery for apical targeting in epithelial cells. The src family kinase Lck plays a pivotal role in T cell signaling. We show that MAL is required in T cells for efficient expression of Lck at the plasma membrane and activation of IL-2 t...

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Bibliografiske detaljer
Main Authors: Antón, Olga, Batista, Alicia, Millán, Jaime, Andrés-Delgado, Laura, Puertollano, Rosa, Correas, Isabel, Alonso, Miguel A.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605221/
https://ncbi.nlm.nih.gov/pubmed/19064697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080552
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