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An essential role for the MAL protein in targeting Lck to the plasma membrane of human T lymphocytes
The MAL protein is an essential component of the specialized machinery for apical targeting in epithelial cells. The src family kinase Lck plays a pivotal role in T cell signaling. We show that MAL is required in T cells for efficient expression of Lck at the plasma membrane and activation of IL-2 t...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2605221/ https://ncbi.nlm.nih.gov/pubmed/19064697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080552 |
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