Coregulation of CD8(+) T cell exhaustion during chronic viral infection by multiple inhibitory receptors

T cell exhaustion often occurs during chronic infections and prevents optimal viral control. The molecular pathways involved in T cell exhaustion, however, remain poorly understood. We demonstrate that exhausted CD8(+) T cells are subject to complex layers of negative regulation due to co-expression...

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Autori principali: Blackburn, Shawn D., Shin, Haina, Haining, W. Nicholas, Zou, Tao, Workman, Creg J., Polley, Antonio, Betts, Michael R., Freeman, Gordon J., Vignali, Dario A. A., Wherry, E. John
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605166/
https://ncbi.nlm.nih.gov/pubmed/19043418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1679
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