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Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies
Previous studies have shown that a dominant negative form of c-Jun (TAM67) suppresses mouse skin carcinogenesis both in vitro and in vivo. The current study identifies Sulfiredoxin (Srx) as a unique target of activator protein-1 (AP-1) activation and TAM67 inhibition. Manipulation of Srx levels by S...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2604998/ https://ncbi.nlm.nih.gov/pubmed/19057013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810676105 |
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