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Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies

Previous studies have shown that a dominant negative form of c-Jun (TAM67) suppresses mouse skin carcinogenesis both in vitro and in vivo. The current study identifies Sulfiredoxin (Srx) as a unique target of activator protein-1 (AP-1) activation and TAM67 inhibition. Manipulation of Srx levels by S...

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Detalhes bibliográficos
Main Authors: Wei, Qiou, Jiang, Hong, Matthews, Connie P., Colburn, Nancy H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604998/
https://ncbi.nlm.nih.gov/pubmed/19057013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810676105
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