Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis

The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. We still know little about the number of genes that underlie these traits, the magnitude of their effects, or the extent to which they interact. Chromosome substitution strains (CSSs) enab...

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Autors principals: Shao, Haifeng, Burrage, Lindsay C., Sinasac, David S., Hill, Annie E., Ernest, Sheila R., O'Brien, William, Courtland, Hayden-William, Jepsen, Karl J., Kirby, Andrew, Kulbokas, E. J., Daly, Mark J., Broman, Karl W., Lander, Eric S., Nadeau, Joseph H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604967/
https://ncbi.nlm.nih.gov/pubmed/19066216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810388105
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