Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis

The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. We still know little about the number of genes that underlie these traits, the magnitude of their effects, or the extent to which they interact. Chromosome substitution strains (CSSs) enab...

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Detalhes bibliográficos
Main Authors: Shao, Haifeng, Burrage, Lindsay C., Sinasac, David S., Hill, Annie E., Ernest, Sheila R., O'Brien, William, Courtland, Hayden-William, Jepsen, Karl J., Kirby, Andrew, Kulbokas, E. J., Daly, Mark J., Broman, Karl W., Lander, Eric S., Nadeau, Joseph H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604967/
https://ncbi.nlm.nih.gov/pubmed/19066216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810388105
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