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Pervasive Cryptic Epistasis in Molecular Evolution
The functional effects of most amino acid replacements accumulated during molecular evolution are unknown, because most are not observed naturally and the possible combinations are too numerous. We created 168 single mutations in wild-type Escherichia coli isopropymalate dehydrogenase (IMDH) that ma...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2958800/ https://ncbi.nlm.nih.gov/pubmed/20975933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001162 |
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