β-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation

We analyzed the effect of conditional, αMHC-dependent genetic β-catenin depletion and stabilization on cardiac remodeling following experimental infarct. β-Catenin depletion significantly improved 4-week survival and left ventricular (LV) function (fractional shortening: CT(Δex3–6): 24 ± 1.9%; β-cat...

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Autori principali: Zelarayán, Laura C., Noack, Claudia, Sekkali, Belaid, Kmecova, Jana, Gehrke, Christina, Renger, Anke, Zafiriou, Maria-Patapia, van der Nagel, Roel, Dietz, Rainer, de Windt, Leon J., Balligand, Jean-Luc, Bergmann, Martin W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604963/
https://ncbi.nlm.nih.gov/pubmed/19073933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808393105
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