Alterations in mitochondrial function and cytosolic calcium induced by hyperglycemia are restored by mitochondrial transcription factor A in cardiomyocytes

Mitochondrial transcription factor A (TFAM) is essential for mitochondrial DNA transcription and replication. TFAM transcriptional activity is decreased in diabetic cardiomyopathy; however, the functional implications are unknown. We hypothesized that a reduced TFAM activity may be responsible for s...

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Autori principali: Suarez, Jorge, Hu, Yong, Makino, Ayako, Fricovsky, Eduardo, Wang, Hong, Dillmann, Wolfgang H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2008
Soggetti:
Cellular and Mitochondrial Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603561/
https://ncbi.nlm.nih.gov/pubmed/19060297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00076.2008
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