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NOVEL ENRICHMENT OF TUMOR CELL TRANSFECTANTS EXPRESSING HIGH LEVELS OF TYPE-4 GLUTATHIONE PEROXIDASE USING 7α-HYDROPEROXYCHOLESTEROL AS A SELECTION AGENT

A novel approach for selecting high expressing cells out of a general population that had been transfected with a construct encoding cytosolic type-4 glutathione peroxidase (GPx4) is reported. The approach is described for GPx4-null COH-BR1 breast tumor cells and is based on use of a highly specific...

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Detalhes bibliográficos
Main Authors: Kriska, Tamas, Levchenko, Vladislav V., Chu, Fong-Fong, Esworthy, R. Steven, Girotti, Albert W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603420/
https://ncbi.nlm.nih.gov/pubmed/18554519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2008.05.022
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