TRAF6 Autoubiquitination-Independent Activation of the NFκB and MAPK Pathways in Response to IL-1 and RANKL

The adapter protein TRAF6 is critical for mediating signal transduction from members of the IL-1R/TLR and TNFR superfamilies. The TRAF6 RING finger domain functions as an ubiquitin E3 ligase capable of generating non-degradative K63-linked ubiquitin chains. It is believed that these chains serve as...

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Bibliographic Details
Main Authors: Walsh, Matthew C., Kim, Gregory K., Maurizio, Paul L., Molnar, Elizabeth E., Choi, Yongwon
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603309/
https://ncbi.nlm.nih.gov/pubmed/19112497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004064
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