Intranasal Vaccination of Recombinant Adeno-Associated Virus Encoding Receptor-Binding Domain of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Spike Protein Induces Strong Mucosal Immune Responses and Provides Long-Term Protection against SARS-CoV Infection

We have previously reported that a subunit protein vaccine based on the receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein and a recombinant adeno-associated virus (rAAV)-based RBD (RBD-rAAV) vaccine could induce highly potent neutralizing Ab resp...

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Autores principales: Du, Lanying, Zhao, Guangyu, Lin, Yongping, Sui, Hongyan, Chan, Chris, Ma, Selene, He, Yuxian, Jiang, Shibo, Wu, Changyou, Yuen, Kwok-Yung, Jin, Dong-Yan, Zhou, Yusen, Zheng, Bo-Jian
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603051/
https://ncbi.nlm.nih.gov/pubmed/18178835
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