A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae

In Saccharomyces cerevisiae, Cdc13 binds telomeric DNA to recruit telomerase and to “cap” chromosome ends. In temperature-sensitive cdc13-1 mutants telomeric DNA is degraded and cell-cycle progression is inhibited. To identify novel proteins and pathways that cap telomeres, or that respond to uncapp...

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Auteurs principaux: Addinall, S. G., Downey, M., Yu, M., Zubko, M. K., Dewar, J., Leake, A., Hallinan, J., Shaw, O., James, K., Wilkinson, D. J., Wipat, A., Durocher, D., Lydall, D.
Format: Artigo
Langue:Inglês
Publié: Genetics Society of America 2008
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Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600956/
https://ncbi.nlm.nih.gov/pubmed/18845848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.092577
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