Diacylglycerols Activate Mitochondrial Cationic Channel(s) and Release Sequestered Ca(2+)

Mitochondria contribute to cytosolic Ca(2+) homeostasis through several uptake and release pathways. Here we report that 1,2-sn-diacylglycerols (DAGs) induce Ca(2+) release from Ca(2+)-loaded mammalian mitochondria. Release is not mediated by the uniporter or the Na(+)/Ca(2+) exchanger, nor is it at...

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Auteurs principaux: Chinopoulos, Christos, Starkov, Anatoly A., Grigoriev, Sergey, Dejean, Laurent M., Kinnally, Kathleen W., Liu, Xibao, Ambudkar, Indu S., Fiskum, Gary
Format: Artigo
Langue:Inglês
Publié: 2005
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600847/
https://ncbi.nlm.nih.gov/pubmed/16167179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10863-005-6634-0
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