Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

The superoxide radical (O(2)(−)) has long been considered a major cause of aging. O(2)(−) in cytosolic, extracellular, and mitochondrial pools is detoxified by dedicated superoxide dismutase (SOD) isoforms. We tested the impact of each SOD isoform in Caenorhabditis elegans by manipulating its five s...

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Bibliografski detalji
Glavni autori: Doonan, Ryan, McElwee, Joshua J., Matthijssens, Filip, Walker, Glenda A., Houthoofd, Koen, Back, Patricia, Matscheski, Andrea, Vanfleteren, Jacques R., Gems, David
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2008
Teme:
Research Communication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600764/
https://ncbi.nlm.nih.gov/pubmed/19056880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.504808
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