NF1 loss disrupts Schwann cell–axonal interactions: a novel role for semaphorin 4F

Neurofibromatosis type 1 (NF1) patients develop neurofibromas, tumors of Schwann cell origin, as a result of loss of the Ras-GAP neurofibromin. In normal nerves, Schwann cells are found tightly associated with axons, while loss of axonal contact is a frequent and important early event in neurofibrom...

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Autors principals: Parrinello, Simona, Noon, Luke A., Harrisingh, Marie C., Digby, Patrick Wingfield, Rosenberg, Laura H., Cremona, Catherine A., Echave, Pedro, Flanagan, Adrienne M., Parada, Luis F., Lloyd, Alison C.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2008
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600763/
https://ncbi.nlm.nih.gov/pubmed/19056885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.490608
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