Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastoma

IGF2, a maternally imprinted foetal growth factor gene, is implicated in many childhood tumours including hepatoblastoma (HB); however, the genetic and epigenetic alterations have not comprehensively been studied. We analysed the methylation status of the H19 differentially methylated region (DMR),...

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Detalhes bibliográficos
Main Authors: Honda, S, Arai, Y, Haruta, M, Sasaki, F, Ohira, M, Yamaoka, H, Horie, H, Nakagawara, A, Hiyama, E, Todo, S, Kaneko, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600691/
https://ncbi.nlm.nih.gov/pubmed/19034281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604754
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