Cancer induction by restriction of oncogene expression to the stem cell compartment

In human cancers, all cancerous cells carry the oncogenic genetic lesions. However, to elucidate whether cancer is a stem cell-driven tissue, we have developed a strategy to limit oncogene expression to the stem cell compartment in a transgenic mouse setting. Here, we focus on the effects of the BCR...

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Detalhes bibliográficos
Main Authors: Pérez-Caro, María, Cobaleda, César, González-Herrero, Inés, Vicente-Dueñas, Carolina, Bermejo-Rodríguez, Camino, Sánchez-Beato, Margarita, Orfao, Alberto, Pintado, Belén, Flores, Teresa, Sánchez-Martín, Manuel, Jiménez, Rafael, Piris, Miguel A, Sánchez-García, Isidro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600654/
https://ncbi.nlm.nih.gov/pubmed/19037256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.253
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